Ovarian and extra-ovarian mediators in the development of polycystic ovary syndrome
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چکیده
منابع مشابه
The Effect of Sitagliptin on Inflammatory Mediators in the Ovary of Rat with Polycystic Ovary Syndrome
Background and Aims: Polycystic ovary syndrome (PCOS) is an endocrine and metabolic disease in females of reproductive age and is a significant infertility cause. Inflammation plays a crucial role in the pathogenesis of PCOS. The present study evaluated whether sitagliptin, dipeptidyl peptidase-4 inhibitor, attenuates inflammatory markers C-reactive protein (CRP), interleukin(IL)-6, tumor necro...
متن کاملThe Effect of Green Tea Extract on Reproductive Improvement in Estradiol Valerate-Induced Polycystic Ovary Polycystic Ovarian Syndrome in Rat
Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disorder in which thelevel of oxidative elements in blood rises. Green tea is a potent antioxidant since it containscatechins. In this study, the effect of hydro-alcoholic green tea extract on PCOS rats was examined.For PCOS induction, 96 mature Wistar rats were given estradiol valerate. After 60 days, therats were divided into fo...
متن کاملThe Effect of Green Tea Extract on Reproductive Improvement in Estradiol Valerate-Induced Polycystic Ovary Polycystic Ovarian Syndrome in Rat
Polycystic ovary syndrome (PCOS) is a reproductive and metabolic disorder in which thelevel of oxidative elements in blood rises. Green tea is a potent antioxidant since it containscatechins. In this study, the effect of hydro-alcoholic green tea extract on PCOS rats was examined.For PCOS induction, 96 mature Wistar rats were given estradiol valerate. After 60 days, therats were divided into fo...
متن کاملCirculating leptin concentrations and ovarian function in polycystic ovary syndrome.
OBJECTIVE Polycystic ovary syndrome (PCOS) is characterized by ovarian dysfunction. Although the role of leptin in the control of reproduction is unclear, it may be involved in the control of ovulation. The aim of this cross-sectional study was to determine the relationship between circulating leptin concentrations, and anthropometric, metabolic and endocrine variables as well as to examine a p...
متن کاملMetformin Therapy Decreases Hyperandrogenism and Ovarian Volume in Women with Polycystic Ovary Syndrome
Background: It is well known that there is a close relationship between elevated androgen plasma levels and the ultrasound findings of stromal hypertrophy in polycystic ovary syndrome (PCOS). The objective of this study was to investigate the effects metformin on the hyperandrogenism and ovarian volume in PCOS. Methods: The study is an unrandomized clinical trial with before–after desig...
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ژورنال
عنوان ژورنال: Journal of Molecular Endocrinology
سال: 2018
ISSN: 0952-5041,1479-6813
DOI: 10.1530/jme-18-0079